Although multi-frame super resolution algorithm has many merits but it demands too much calculation time. Researches have shown that image processing time can be reduced using a CUDA(Compute unified device architecture) which is one of GPGPU(General purpose computing on graphics processing unit) models. In this paper, we show that the processing time of multi-frame super resolution algorithm can be reduced by employing the CUDA. It was applied not to the whole parts but to the largest time consuming parts of the program. The simulation result shows that using a CUDA can reduce an operation time dramatically. Therefore it can be possible that multi-frame super resolution algorithm is implemented in real time by using libraries of image processing algorithms which are made by a CUDA.