Purpose: This study was to understand and explain the adjustment of cancer patients receiving chemotherapy. Variables in this model were social support, uncertainty, resilience and coping. Methods: The data were collected for approximately five months from May through to September 2006 with cancer patients receiving chemotherapy or cancer patients finished chemotherapy using self-administered questionnaires. Descriptive statistics program, Amos 5.0, was employed to verify the goodness of the hypothetic model and the hypotheses formulated in the study. Results: The fitness of the finalized model turned out to be improved ($X^2$=332.644, df=70, GFI= .809, AGFI= .714, RMSEA= .138, AIC=402.644). Those variables made a 60.8% prediction of the patients adjustment. Conclusion: The hypothetic model presented in the study could serve to explain the adjustment of cancer patients receiving chemotherapy. Moreover, the use of the conceptual framework of the theory of planned nursing intervention would be very worthwhile as a strategy to boost the adjustment of cancer patients when receiving chemotherapy.