With the proliferation of the e-Book industry, people are increasingly interacting with e-Book as information systems. While e-Book contains the components regarded as an information system(IS), few studies have been conducted to assess the success of e-Book from IS perspective. This study proposed and empirically evaluated an e-Book success model. Structural equation modeling techniques were applied to the data collected by questionnaire from 241 users of e-Book. Every relationship among constructs was significantly supported by the data. This finding provided theoretical implications to extend existing e-Book research into the broader IS research area. Furthermore, this study illustrated the use of multi-group structural analysis to test the differences in structural weights between high e-Book and high paper book utility groups. The managerial implications of the results in setting different relationships and allocating appropriate paths to vitalize the e-Book market were discussed.