This study presents sealing characteristics of multi-contact o-rings as functions of strain, compression stress, and contact normal stress using a FEM technique. The FEM results on the sealing characteristics show that the maximum strain, maximum compression stress, and maximum contact normal stress of multi-contact o-rings are approximately 1.7 times higher than those of conventional o-rings. This is due to a U-grooved cross section of multi-contact o-rings, and the multi-contact o-rings with a U-groove show more effective in sealing for high pressure vessels, valves, and gas equipments. And the extrusion failure in the multi- contact o-ring does not produce for an increased gas pressure due to a U-groove. This may extend sealing life compared to that of a conventional o-ring.