There are PFD(Process Flow Diagram) and P&ID(Piping and Instrument Diagram) for designing and managing chemical process efficiently. They provide the operation condition and equipment specifications of chemical process, but they do not provide the reliability of chemical process. Therefore, in this study, Reliability Flow Diagram(RFD) which provide the cycle and time of preventive maintenance has been developed using Directed Graph Analysis methodology. Directed Graph Analysis methodology is capable of assessing the reliability of chemical process. It models chemical process into Directed Graph with nodes and arcs and assesses the reliability of normal operation of chemical process by assessing Directed Graph sequential. In this paper, the chemical process reliability transition according to operation time was assessed. And then, Reliability Flow Diagram has been developed by inserting the result into P&ID. Like PFD and P&ID, Reliability Flow Diagram provide valuable and useful information for the design and management of chemical process.