Inconel 718 alloy has been widely used in the aerospace, heavy industry and electronic industry. However, the machinability of this alloy is very poor, which is attributed to their inherent high strength that is maintained at elevated temperatures. The tool life is dominant problem in machining difficult-to-cut materials, so it is necessary to select the efficient cutting conditions for the improvement of tool life. In this study, the cutting force, tool wear and surface roughness are investigated in end milling machining under various cutting conditions. By this experiment, the efficient machining condition of this alloy is suggested to adopt in various industries.