Objectives: Existing cardiovascular simulators are used to evaluate artificial organs such as artificial hearts, prosthetic valves, and artificial blood vessels, and pulses are typically triggered using artificial hearts. However, the forms of pulse waves vary according to the location of arteries, and for precise assessment of artificial blood vessels, the development of simulators that generate diverse pressure pulse waves is necessary. This study developed a novel cardiovascular simulator that generates different forms of pulse waves. Methods: This simulator consists of a stepping motor, a slider-crank mechanism that transforms the rotation movement of a motor into the straight-line motion of a piston, a piston that generates pulsatile flows, a water tank that supplies fluids, an elastic tube made of silicon, and a device that adjusts the terminal resistance of fluids. Results & Conclusion: This study examined motor rotation and its operation under conditions similar to the physiological conditions of the heart. The simulator developed in this study produced diverse forms of waves, and the generated pressure waves well satisfied physiological conditions.