The aim of this study was to compare the spray characteristics of a typical fuel (100% diesel, DME) and diesel-DME blended fuel in a constant volume combustion chamber (CVCC). The typical fuel (100% diesel, DME) and diesel-DME blended fuel spray characteristics were investigated at various ambient pressures (pressurized nitrogen) and fuel injection pressures using a common rail fuel injection system when the fuel mixture ratio was varied. The fuel injection quantity and spray characteristics were measured including spray shape, penetration length, and spray angle. Common types of injectors were used.