Purpose: This study is a methodological study to develop education program for families of patients with brain injury. Method: This education program is on the basis of education items identified in a previous research, and literature review, and again this was developed by educational program for families of patients with brain injury that consist of items which pass through proof of content validity of special group. This study established the goal of the study about selected items and made out a preliminary education program, and it was reviewed and corrected by evidence of content validity of the special group and the degree of difficulty. Results: The final education program content consists of 6 areas. : disease, cure and care, rehabilitation, family and others. Conclusion: This program will expect to be utilized to keep optimal health state, also it can prevent various problems from happening to patients with brain injury; moreover, we expect that it would improve the quality of life.