- 중국.베트남 약용식물의 최종당화산물 생성저해활성 검색(VIII)
- ㆍ 저자명
- 최소진,송유진,김영숙,김주환,김진숙,Choi. So-Jin,Song. Yoo Jin,Kim. Young Sook,Kim. Joo Hwan,Kim. Jin Sook
- ㆍ 간행물명
- 생약학회지
- ㆍ 권/호정보
- 2012년|43권 4호|pp.338-344 (7 pages)
- ㆍ 발행정보
- 한국생약학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
Advanced glycation end products (AGEs) have been postulated to play a central role in the development of diabetic complications. A variety of different agents that inhibit AGEs have been under investigation. In this study, 62 herbal medicines from China and Vietnam have been investigated with an in vitro evaluation system using AGEs formation inhibitory activity. Of these, 5 herbal medicines ($IC_{50}$ < $5{mu}g/ml$) were found to have significant AGEs formation inhibitory activity. Particularly, herbal medicines Albizia odoratissima (twigs and leaves), Rhododendron spinuliferum (twigs and leaves), Dioscorea cirrhosa (stems and leaves), Illicium verum (stems and leaves) and Aglaia perviridis (stems and leaves), showed more potent inhibitory activity (approximately 16-26 fold) than the positive control aminoguanidine ($IC_{50}=76.47{mu}g/ml$).