This study was to identify the mediating effect of hope between acculturative stress and psychological wellbeing of women immigrants. The data for the study were collected from 609 women immigrants in 10 cities and provinces of Korea. First, the acculturative stress except for homesickness was lower than the middle point, and hope and positive wellbeing scored above the middle point. Second, acculturative stress was negatively correlated with hope and positive wellbeing. Third, the mediating effect of hope between acculturative stress and positive wellbeing was testified. Finally, the mediating effect of hope between acculturative stress and negative wellbeing was also testified.