The End Coupling is main component of the aluminum hot roll process. The End Coupling is used for transmission of rotational power with heavy-duty load. Fracture of the End Coupling cause serious economic losses because an End Coupling is a very expensive component and it takes a long time to repair it. Therefore, preventing the destruction of the End Coupling is essential for ensuring a long mechanical life cycle. In this paper, the parametric study on the End Coupling was performed in order to minimize maximum stress under operation loads. To verify the interference of spindle assembly with modified End Coupling, kinematics simulation was performed by applying the various combination type and dynamic boundary condition of the spindle assembly. The interference of optimized model was not occurred during combination process and driving process. As a result of an optimum design for life extension on End Coupling, the maximum stress of modified End Coupling was lower than that of the initial model by 26%.