The present study was conducted to investigate the flame instability(evaluated by Markstein length and cellular instability) and laminar burning velocity in a constant volume combustion chamber at room temperature and elevated pressure up to 0.3 MPa to suggest the possibility of utilizing mixtures of syngas added DME-air premixed flames in internal combustion engines. The experimentally measured laminar burning velocities were compared to predictions calculated the PREMIX code with Zhao reaction mechanism. Discussions were made on effects of syngas addition into DME-Air premixed flames through evaluating laminar burning velocity, Markstein length, and cellular instability. Particular concerns are focused on cellular instability caused by hydrodynamic instability and diffusive-thermal instability.