Purpose: The purpose of this study was to investigate the factors affecting adaptation to school life of freshmen enrolled in nursing at a Junior College. Method: The data were collected from questionnaires filled out by 312 nursing students in two schools at J and I city from March 7-11, 2011. Data were analyzed using the SPSS/WIN18 program. Result: Self-esteem and adaptation to school life were higher than previous advanced research showed, self-efficacy was moderate and stress to school life was lower than other studies. School adaptation level was related to satisfaction of friendship, school life and the nursing program. The subjects who have chosen nursing by themselves and male students scored higher in their school adaptation. The greatest factors affecting adaptation to school life were satisfaction of school life and stress respectively. Conclusion: Inpre-admission, enough information about nursing school life through experience of previous students must be given. Then, a school adaptation program which incorporates counseling and mentoring should be provided for supporting understanding of school life.