참비름의 $in$ $vitro$ 라디칼 소거활성 및 콜레스테롤 급이 흰쥐에 보충 급이할 경우 혈액 중 지질 성분의 함량에 미치는 영향을 분석하였다. 참비름 물 및 80% 에탄올 추출물의 ABTS, DPPH 및 nitric oxide 라디칼 소거활성은 물 추출물보다 에탄올 추출물에서 유의적으로 높았다. 콜레스테롤을 급이한 대조군에 비해 5%(HCA1) 및 10%(HCA2)의 참비름 분말 급이 시 혈청 총 지질, 총 콜레스테롤 함량, 동맥경화지수 및 심혈관질환 위험지수는 시료의 첨가량이 증가됨에 따라 유의적으로 감소하였다. 중성지방은 HCA2군에서만 유의적인 감소를 보였으며, HDL-콜레스테롤은 대조군에 비해 참비름 분말 급이 시 증가하였으나, 첨가량에 따른 유의차는 없었다. 혈중 GPT 및 ${gamma}$-GTP 활성은 대조군에 비하여 참비름 분말 급이군에서 유의적으로 감소하였다. 혈중 지질과산화물 함량도 같은 경향이었다. 따라서 참비름은 식이성 콜레스테롤에 의한 질환의 조절에 유효할 것으로 생각된다.
To evaluate of biological activity of Chambirum ($Amaranthus$ $lividus$) $in$ $vitro$ and $in$ $vivo$, we investigated the free radical scavenging activity of its extracts $in$ $vitro$ and the effect of lyophilized powder on the serum lipid profile of rats fed cholesterol. ABTS, DPPH, and NO radical scavenging activities were tested from water and 80% ethanol extracts of Chambirum, and biological activities of the ethanol extracts were significantly higher than the water extracts. The total lipid and total cholesterol content of serum, atherogenic index (AI), and cardiac risk factor (CRF) were decreased significantly for the groups fed with a 5% and 10% supplement of Chambirum powder (HCA1 and HCA2) in comparison with the group fed cholesterol (HC). Triglyceride content decreased drastically in the HCA2 group, while its content was not decreased in the other group. HDL-cholesterol content was elevated in the HCA1 and HCA2 groups, but was not significantly different to the supplemented amount of Chambirum powder. GPT and ${gamma}$-GTP activities were decreased significantly in the groups fed with Chambirum powder compared to the HC group. And the content of the lipid peroxide level was the same trend. Therefore, these results give evidence that Chambirum might be useful in the control of induced disorders by dietary cholesterol and/or lipids.
