The spatial variation of ground motion in Kolkata Metropolitan District (KMD) has been estimated by generating synthetic ground motion considering the point source model coupled with site response analysis. The most vulnerable source was identified from regional seismotectonic map for an area of about 350 km radius around Kolkata. The rock level acceleration time histories at 121 borehole locations in Kolkata for the vulnerable source, Eocene Hinge Zone, due to maximum credible earthquake (MCE) moment magnitude 6.2 were generated by synthetic ground motion model. Soil investigation data of 121 boreholes were collected from the report of Soil Data Bank Project, Jadavpur University, Kolkata. Surface level ground motion parameters were determined using SHAKE2000 software. The results are presented in the form of peak ground acceleration (PGA) at rock level and ground surface, amplification factor, and the response spectra at the ground surface for frequency 1.5 Hz, 3 Hz, 5 Hz and 10 Hz and 5% damping ratio. Site response study shows higher PGA in comparison with rock level acceleration. Maximum amplification in some portion in KMD area is found to be as high as 3.0 times compared to rock level.