Precast segmental bridge columns (PSBC) are alternatives for monolithic cast-in-situ concrete columns in bridge substructures, with fast construction speed and structural durability. The analytical tool for common use is demonstrated applicable for seismic performance prediction of PSBCs through experiment conducted earlier. Then the analytical program was used for parameter optimization of PSBC configurations under reversal cyclic loading. Shear strength by pushover analysis was compared with theoretical prediction. Moreover, seismic response of PSBC with energy dissipation (ED) bars was compared with its no ED bar counterpart under three history ground acceleration records. The investigation shows that appropriate ED bar and post-tensioned tendon arrangement is important for higher lateral bearing capacity and good ductility performance of PSBCs.