Purpose: The purpose of this study was to determine the effect of monochromatic infrared energy (MIRE) on the blood flow of the superficial radial artery and local skin temperature in healthy subjects. Methods: Forty healthy volunteers were recruited and randomly assigned to MIRE group (n=20) and placebo group (n=20). The MIRE group received a 890 nm MIRE irradiation on the forearm using two therapy pads for 30 minutes. The therapy pad was composed of an array of 60 diodes. MIRE unit was set at bar 8, that corresponds to a diode power of 10 mW and a power density of $63mW/cm^2$. The placebo group received sham MIRE. Peak blood flow velocity (PBFV), mean blood flow velocity (MBFV), and skin temperature (ST) were measured pre- and post-MIRE irradiation. Results: There was a significant difference in PBFV (p<0.001), MBFV (p<0.001), and ST (p<0.001) between the pre- and post-treated values in the MIRE group. In contrast, no significant difference was found between the pre- and post-treated values in the placebo group. There was significant difference in mean change values from baseline of PBFV (p<0.001), MBFV (p<0.001), and ST (p<0.001) between the MIRE group and the placebo group. There was a significant increase in PBFV (p<0.001), MBFV (p<0.001), and ST (p<0.001) following MIRE irradiation. Conclusion: The arterial blood flow and local skin temperature of the forearm in the healthy subjects were significantly increased following MIRE irradiation.