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Clinical application of anti-M$ddot{u}$llerian hormone as a predictor of controlled ovarian hyperstimulation outcome
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  • Clinical application of anti-M$ddot{u}$llerian hormone as a predictor of controlled ovarian hyperstimulation outcome
  • Clinical application of anti-M$ddot{u}$llerian hormone as a predictor of controlled ovarian hyperstimulation outcome
저자명
Lee. Jae Eun,Lee. Jung Ryeol,Jee. Byung Chul,Suh. Chang Suk,Kim. Ki Chul,Lee. Won Don,Kim. Seok Hyun
간행물명
Clinical and experimental reproductive medicine
권/호정보
2012년|39권 4호|pp.176-181 (6 pages)
발행정보
대한생식의학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Objective: In 2009 anti-M$ddot{u}$llerian hormone (AMH) assay was approved for clinical use in Korea. This study was performed to determine the reference values of AMH for predicting ovarian response to controlled ovarian hyperstimulation (COH) using the clinical assay data. Methods: One hundred sixty-two women who underwent COH cycles were included in this study. We collected data on age, basal AMH and FSH levels, total dose of gonadotropins, stimulation duration, and numbers of oocytes retrieved and fertilized. Blood samples were obtained on cycle day 3 before gonadotropin administration started. Serum AMH levels were measured at a centralized clinical laboratory center. The correlation between the AMH level and COH outcomes and cut-off values for poor and high response after COH was analyzed. Results: Concentration of AMH was significantly correlated with the number of oocytes retrieved (OPU; r=0.700, p<0.001). The mean${pm}$SE serum AMH levels for poor ($OPU{leq}3$), normal ($4{leq}OPU{leq}19$), and high ($OPU{geq}20$) response were $0.94{pm}0.15$ ng/mL, $2.79{pm}0.21$ ng/mL, and $6.94{pm}0.90$ ng/mL, respectively. The cut-off level, sensitivity and specificity for poor and high response were 1.08 ng/mL, 85.8%, and 78.6%; and 3.57 ng/mL, 94.4%, and 83.3%, respectively. Conclusion: Our data present clinical reference values of the serum AMH level for ovarian response in Korean women. The serum AMH level could be a clinically useful predictor of ovarian response to COH.