In this paper, a general solution to the field equations of generalized thermodiffusion in an infinite thermoelastic body with a spherical cavity has been obtained in the context of the theory of generalized thermoelastic diffusion. The bounding surface of the sphere is subjected to periodic loading and the temperature and chemical potential are assumed to be zero on the curved surface. The generalized theory of thermoelasticity is applied to account for finite velocity of heat propagation. The closed form solutions for distributions of displacement, temperature and stresses are obtained. The solutions valid in the case of small frequency are deduced and the results are compared with the corresponding results obtained in other generalized thermoelasticity theories. Numerical results applicable to a copper-like material are also presented graphically and the nature of variations of the physical quantities with radial coordinate and with frequency of vibration is analyzed.