Current research trends in wood preservatives for enhancing durability was reviewed. Due to leaching of recent Copper-Based Preservatives commonly used as chemicals for pressure treatment; they have been a growing concern, especially in improving the fixation of the copper as alkyl ammonium quat. and azol in wood and preventing the leaching of active ingredients. With the appearance of emulsion type chemicals using micronized and nano-sized wood preservatives, researchs on characteristics of Copper-Based Preservatives regarding penetration and fixation in wood are debatable. Moreover, unlike the case of CCA, the recent alkyl ammonium quat. and azol bear a serious threat in the decrease of antimicrobial effectiveness against wood destroying fungi with copper tolerance. Therefore, development and research of co-biocide is needed.