Data corruption in SCADA systems refers to errors that occur during acquisition, processing, or transmission, introducing unintended changes to the original data. In SCADA-based power systems, the data gathered by remote terminal units (RTUs) is subject to data corruption due to noise interference or lack of calibration. In this study, an effective approach based on the fusion of the general regression neural network (GRNN) and the particle swarm optimization (PSO) technique is employed to deal with errors in RTU data. The proposed hybrid model, denoted as GRNN-PSO, is able to handle noisy data in a fast speed, which makes it feasible for practical applications. Experimental results show the GRNN-PSO model has better performance in removing the unintended changes to the original data compared with existing methods.