Recently metropolitan cities pursue multi centric urban spatial structure for sustainable development and efficient urban management. Thus, this study calculated population potential using data on population distributed among road nodes for the last 50 years, and based on the results. We measured the spatial variability of the multi centric structure of Busan Metropolitan City. According to the results, the multi centralization process has been continued up to recently in Busan Metropolitan City. As population potential is concentrated on sub centers, Hadan, Gupo and Haeundae areas were playing an increasingly powerful role as the center of the respective district, and Sasang and Dongrae had been losing their role as the center of their respective districts since 2000 and 1990, respectively. Additionally, in all the multi centric districts except Haeundae was observed the increase of oblongity, which is the change of spatial structure in an unbalanced way toward a specific area or direction.