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포공영(浦公英) 물 추출물의 항당뇨 효과에 대한 연구
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  • 포공영(浦公英) 물 추출물의 항당뇨 효과에 대한 연구
저자명
오찬호,신남식,권진,이광규,이상룡,이창현,Oh. Chan Ho,Shin. Nam Sik,Kwan. Jin,Lee. Kwang Gyu,Lee. Sang Ryong,Lee. Chang Hyun
간행물명
동의생리병리학회지
권/호정보
2012년|26권 5호|pp.707-713 (7 pages)
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대한동의생리학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Taraxacum coreanum Nakai (TM) has been investigated for its antidiabetic activity in streptozotocin induced diabetic animals, but few studies have been conducted to evaluate its efficacy for treatment of type II diabetic mice. This study was designed to evaluate the efficacy of the water extracts of TM for the treatment of type II diabetes. Twenty four mice(C57BLKS/J Iar $-+Lepr^{db}/+Lepr^{db}$) with type II diabetes were randomly assigned either to a experimental group A (leaves extraction of TM), experimental group B(roots extraction of TM), experimental group C(leaves, roots and flowers extraction of TM) or control group. Water extracts of TM were ingested for 10 weeks. The changes of body weight, level of blood glucose, numerical change of insulin-immunoreactive cells and level of blood insulin were measured after treatment of water extracts of TM. A reduction of the blood glucose level after treatment of TM was observed in all the experimental groups. Especially, experimental C group showed significant reduction of blood glucose level compared with control group. Experimental C group induced an increase the level of blood insulin and density of insulin immunoreactive cells after treatment of TM. These results show that water extracts of TM can improve the severity in type II diabetic mice.