The aim of this study was to optimize S-tube shape of heat exchanger in term of reducing the size of tube bundle and improving the mechanical properties such as the thermal stress and resonance. The geometric parameters such as offset length, the straight distance between one end and other end of tube, the tube length in straight portion and fillet radius was assessed as a valid parameters. The structural analysis was performed to estimate the structural characteristics. Main effect analysis was performed to investigate the main effect for the various geometric parameters. The response surface methodology was employed to establish mathematical approximation models as a function of the geometric parameters of the S-tube. Also, The optimization was performed to optimize geometric parameters of S-tube using the regression equations and optimization tool. The optimized tube shape has been proposed. Those could be used in the heat exchanger design used in high temperature.