In this study, we evaluated the effects of silicone-based gel on the healing of hypertrophic scars in the rabbit ear model. After 4-week application of silicone-based gel containing allantoin, dexpanthenol and heparin (Noscarna$^{TM}$) to scars in a rabbit ear model of hypertrophic scarring, significant improvements in hypertrophic scar healing and a great loss of skin pigment were observed compared to the non-treated control, base or silicone control-treated scars. Furthermore, histological analysis of Noscarna$^{TM}$-treated scars revealed a significant reduction in scar elevation index (SEI), anterior skin and epithelial thicknesses, inflammatory cells, vessels, collagen disorganization and fibroblasts compared to all control hypertrophic scars. Furthermore, Noscarna$^{TM}$ showed more favorable effects on hypertrophic scars than a commercial product, Contractubex$^{(R)}$. Therefore, these results clearly demonstrated that the newly developed silicone-based gel, Noscarna$^{TM}$, could be a promising formulation as an effective therapeutic agent for hypertrophic scars.