The effect of spinning parameters on core-spun yarns properties manufactured using three-strand modified method (TSMM) was analyzed. Of the various spinning parameters, strand spacing, yarn linear density and yarn twist have a crucial effect on core-spun yarn properties. To achieve the objectives of this research, general physical properties of core-spun yarns together with existing standards were thoroughly studied. First of all, the strand spacing and yarn linear density were optimized. Afterwards, the effects of variation of yarn twist and sheath roving linear density on core-spun yarns properties were investigated. Finally, the physical and mechanical properties of TSMM yarns were compared with those of siro and conventional ring core-spun yarns counterparts. It was found that, the best strand spacing and yarn linear density to produce core-spun yarns are 8 mm and 45 tex, respectively. Results showed that, tenacity of TSMM yarns increases up to a certain twist level beyond which it reduces. The result confirmed that 45 tex yarns produced by three rovings of the same count are superior with regards to tenacity and hairiness. The optimized yarns produced by three-strand modified method enjoy superior physical and mechanical properties in comparison to the ring and siro core-spun yarns.