For the past few years, the concern for clean energy has been greatly increased. Ocean thermal Energy Conversion(OTEC) power plants are studied as a viable option for the supply of clean energy. In this study, we examined the thermodynamic performance of the OTEC power system for the production of electric power. Computer simulation programs were developed under the same condition and various working fluids for closed Rankine cycle, regenerative cycle, Kalina cycle, open cycle, and hybrid cycle. The results show that the regenerative cycle showed the best system efficiency. And then we examined the thermodynamic performance of regenerative cycle OTEC power system using the condenser effluent from Uljin nuclear power plant instead of the surface water. The highest system efficiency of the condition was 4.55% and the highest net power was 181 MW.