PLGA is a FDA-approved biocompatible and biodegradable polymer that is widely used in biomedical fields including drug delivery. Micro and nanoparticles based on PLGA have been extensively studied as drug delivery systems. Numerous studies proved that PLGA particulate systems are highly promising drug carriers for tumor targeting as well as pulmonary, oral, ophthalmic and vaginal delivery. PLGA particles can load a variety of classes of drugs including peptides, proteins and siRNA, protect unstable drugs in the body and have an ability to adapt versatile surface functionalities. PLGA particle systems have evolved with advancement of nano and biotechnology in the past decade. This review focuses on novel and innovative PLGA-based particulate drug delivery carriers in recent years.