The study provides the direction for constructing and operating ELN(Electronic Laboratory Notebook) system for systematic record, management and reliability security of the document. Firstly, Present the standard of the system environment for writing and management of ELN. Secondly, Establish guidelines for systematic maintenance and operation of ELN system. Thirdly, Draw up guidelines of inspection whether ELN system is managed in according with the standards and procedures. Therefore, it is expected that these guidelines contribute to vitalize ELN and set foundation of application for researching and developing information in the medium and long term.