The precise control of internal pressure and axial force loading paths significantly affects the final product quality. In this study, the effect of tube dimensions on the pressure and force loading paths in tube hydroforming process is investigated by using simulated annealing optimization method linked to a commercial finite element code. The optimized loading paths, obtained for different tube geometries with a constant expansion ratio, are then compared. The effects of initial diameter and wall thickness on shape conformation, optimal internal pressure and axial force (or feed) are discussed on the basis of optimal loading paths. Several guidelines in prediction and determination of tube hydroforming parameters are obtained by optimization analysis.