Water extract of ginseng was fermented using various lactic acid bacteria, and their anti-Helicobacter pylori activity was evaluated. The fermented ginseng extracts evidenced anti-H. pylori activity, including anti-bacterial, anti-adhesion, and urease inhibition effects. Among the four types of lactic acid bacteria, Lactobacillus plantarum MG 208 evidenced the most profound anti-H. pylori activity in fermented ginseng. Therefore, fermented ginseng extract containing L.plantarum MG 208 could prove useful as functional diet for the protection of the gastric environment against H. pylori.