Vitamin E exists in cellular membranes and has been shown to inhibit consecutive oxidative reactions that occur inside and outside of the cellular membrane. It significantly reduces oxidative stress caused by various factors, and vitamin E radicals can be transformed into vitamin E by interacting with vitamin C and glutathione. Thus, long- and short- term effects of vitamin E on skin tissues caused by stress in young age were examined. Stress decreased the width of the dermal layer, elasticity, and collagen content of the skin and increased the width of the epidermal layer, forming wrinkles. However, administration of vitamin E protected the skin when subjected to stress, resulting in higher skin elasticity, thicker width of the dermal layer and thinner epidermal layer than skin without administration of vitamine E. These results suggest that vitamine E has a positive effect on protecting skin when under stress.