In this paper, we investigated an implementation of anti-fire monitoring system based on the RS-485 communication to support local area coverage within a range of 1 Km range. We developed a Multi Point Communication Protocol supporting input/output information processing and control up to 8128 terminal check points, which provides an interface between the anti-fire monitoring system receiver and multiplex transponders. Additionally, a multiplex transponders controller has been designed for the implemented system to comply with the government regulation on fire protection, especially to monitor, report and control 1016 terminal check points within the time limit.