The comparison between the spatial and temporal variability of aridity index, precipitation effectiveness and runoff during El-Nino and La-Nina periods and that of the normal period was conducted to evaluate the regional impacts of El-Nino, La-Nina in hydrologic variables. Aridity index and precipitation effectiveness were estimated using 59 nationwide weather stations data and runoff data of WAMIS were used. The ratio of the difference between El-Nino, La-Nina year value and that of normal year was analyzed. Temporal variation demonstrated that aridity index, precipitation effectiveness and run-off discharge increase in March, April, August, November, December and decrease in February, June, September, October according to El-Nino effect. Aridity index, precipitation effectiveness and run-off discharge increase in March, May, September and decrease in June, August, November, December according to La-Nina effect. The spatial variation of those variables analyzed for different basins showed that impacts in the Han river basin relatively higher than that of other basins.