There are lots of analysis to determine the relation between dependent variable and explanatory variables. Often the regression analysis is used to do this, and we can analyze the how much the explanatory variable can be related with dependent variable and how much the regression model can explain the data. But the validation check of regression model is usually determined by coefficient of determination. We should check the validation of regression coefficient with different methods. This paper introduces the method for validation check the regression coefficient using the jackknife regression and bootstrap regression in clinical data.