Durability performance evaluation of automotive components is very important and time consuming task. In this paper, to reduce vehicle component development time and cost virtual testing simulation technology is used to evaluate durability performance of a passenger car front aluminum sub-frame. Multibody dynamics based vehicle model and virtual test simulation model of a half car road simulator are validated by comparisons between rig test results and simulation results. Durability life prediction of the sub-frame is carried out using the model with road load data of proving ground which can evaluate accelerated durability life. We found that the durability performance of the sub-frame is sufficient and it can be predicted within short time compared to rig test time.