High economic growth causes increase of the building energy consumption. The energy consumption for HVAC system accounts for 40~50% of the whole building consumption. The trend for building is large-scale and high-rise. Because of the trend, the energy consumption is becoming bigger than before. Nowadays, HVAC system design are recognized as the solution for a energy-saving. This paper is focused on the energy performance evaluation of central air-conditioning system(water-based) and system air-conditioning that were applied to the office building. The systems are modeled and simulated by using EnergyPlus Software 6.0. After the Simulation, annual cooling and heating energy consumption were calculated. It was found that the system air-conditioning can reduce the energy consumption approximately 55.24% annually compared with the central air-conditioning system(water-cooled). In addition, about 46.13% of annual operating costs can be reduced by use of system air-conditioning.