Mikania micrantha, a neo-tropical vine, is spreading rapidly in the tropical part of Nepal and is now threatening the rural ecosystem including biodiversity and rural livelihoods. However, no attempt has been made to control the spread of M. micrantha. As a result, the vines are spreading freely and rapidly. After a thorough literature review and assessment of forest management practices, we proposed a manual cutting method, as it suits the Nepalese situation for several reasons: required labor is readily available, as local communities are managing forest patches, and the method does not have any potential adverse effects on non-target native species. Experimental plots were laid out in August 2011 to examine the effectiveness of manual cutting. Two different site types based on canopy coverage were selected and divided into three blocks based on cutting strategy. Four treatments were assigned across the experimental plots following a complete block design. We harvested above-ground biomass according to the assigned treatment. The results suggested that there should be at least two consecutive cuttings within a 3-week interval before flowering, and that three consecutive cuttings resulted in 91% mortality of the vines. In addition, cutting promoted regeneration of native plant species. Employing regular cutting operations can modify understory shade enhancing regeneration of native species, which is a desirable condition to constrain proliferation of M. micrantha. Periodic cuttings reduced the competitiveness of M. micrantha regardless of canopy openness, but native ground cover should be retained.