A TPMS(Tire Pressure Monitoring System) is a wireless communication system designed to monitor the pressure and temperature of pneumatic tires of a vehicle. In order to provide the aid in protecting a driver, this system reports tire pressure information to the driver of the vehicle. Since the wireless communication technique should be employed to transmit the TPMS data from each tire to signal processing unit in the vehicle, it suffers from interference signals from external electrical or electronics equipments. In this paper, we propose the TPMS interference cancellation technique based on GSC(Generalized Sidelobe Canceler), which does not have only the excellent performance like MVDR(Minimum-Variance-Distortionless-Response) but also has the low computational complexity comparing with MVDR. The performance of interference suppression is conformed by computer simulation examples.