Picture Archiving and Communication System (PACS) has been planted as one of the key infrastructures with an overall improvement in standards of medical informationization and the stream of digital hospitalization in recent days. The kind and data of digital medical imagery are also increasing rapidly in volume. This trend emphasizes the medical image compression for storing large-scale medical image data. Digital Imaging and Communications in Medicine (DICOM), de facto standard in digital medical imagery, specifies Run Length Encode (RLE), which is the typical lossless data compressing technique, for the medical image compression. However, the RLE is not appropriate approach for medical image data with bilateral symmetry of the human organism. we suggest two preprocessing algorithms that detect interested area, the minimum bounding rectangle, in a medical image to enhance data compression efficiency and that re-code image pixel values to reduce data size according to the symmetry characteristics in the interested area, and also presents an improved image compression technique for brain CT imagery with high bilateral symmetry. As the result of experiment, the suggested approach shows higher data compression ratio than the RLE compression in the DICOM standard without detecting interested area in images.