This paper proposes a multiplexed space-frequency block coding (SFBC) technique for single-carrier modulation with frequency domain equalization. Multiplexed space-frequency block coding technique for single-carrier modulation uses multiple groups of two transmitters and suppresses the interference signals of other SFBC groups at the receiver. In this paper, we reconfigure transmit signals to adapt them for multiplexed SFBC for single-carrier modulation with frequency domain equalization and receiver structures and propose a structure for transmitter and receiver, show its performance is better than the traditional algorithm by simulations.