The Arabian Gulf region has one of the highest ocean temperatures, reaching above 35 degrees and ambient temperatures over 50 degrees in the summer. Two nuclear power plants (NPP) are being introduced in the region for the first time, one at Bushehr (1,000 MWe PWR plant from Russia), and a much larger one at Barakah (4X1,400 MWe PWR from Korea). Both plants take seawater from the Gulf for condenser cooling, having to modify the secondary/tertiary side cooling systems design by increasing the heat transfer surface area from the country of origin. This paper analyses the secondary side of a typical PWR plant operating under the Rankine cycle with a simplified thermal-hydraulic model. Parametric study of ocean cooling temperatures is conducted to estimate thermal efficiency variations and its associated design changes for the secondary side. Operational safety is reviewed to deliver rated power output with acceptable safety margins in line with technical specifications, mainly in the auxiliary systems together with the cooling water temperature. Impact on the Gulf seawater as the ultimate heat sink is considered negligible, affecting only the adjacent water near the NPP site, when compared to the solar radiation on the sea surface.