Purpose: The purpose of this study was to determine the effects of the hand acupressure and lumbar strengthening exercise on young adult women with back pain. Methods: The study used a nonequivalent control group pretest-posttest design. The subjects consisted of 37 female young adults (19 persons in the experimental group and 18 persons in the control group). The hand acupressure and strengthening exercise for lower back were developed by the investigator and a hand acupressure expert. The experimental group was exposed to this program 5 days a week for 4 weeks. The visual analog scale, back muscle strength, flexibility, and quality of life were used as measurement instruments. The data were analyzed with frequency, t-test, and repeated measures ANOVA using SPSS 18.0. Results: In this study, the hand acupressure and strengthening exercise showed siginificant effects on the back muscle strength, flexibility, and quality of life in the experimental group compared to the control group. However, back pain score was not significantly decreased after the program. Conclusion: The study suggests that this program can be applied for the women with low back pain in order to enhance the back muscle strength, flexibility, and quality of life.