Purpose: This study was to identify the relations between stress and health locus of control in nursing college students. Methods: A total of 243 subjects aged between 17 and 27 were selected through convenient sampling. Data were collected with a self reported questionnaire from March 2 to 25, 2013. Collected data were analyzed with SPSS/PC Win 15.0. Results: Differences in stress and health locus of control according to general characteristics were as follows. Stress were significantly different according to gender (t=-2.51, p<.05), grade (F=5.40, p<.01), school record (F=5.72, p<.01), stress solving methods (F=2.62, p<.05). Internal health locus of control was significantly different according to gender (t=2.30, p<.05), grade (F=14.73, p<.001), religion (F=4.63, p<.01), school record (F=5.29, p<.01), economic state (F=5.50, p<.001) and smoking (F=4.17, p<.05). Chance health locus of control was significantly different according to sibling rank (F=2.86, p<.05). Except chance health locus of control, internal heath locus of control and dependence health locus of control have a negative correlation with stress. 15.6% of variance in stress was explained by dependence health locus of control, chance health locus of control, and grade. Conclusion: The findings of this study may be useful in understanding the stress expression of nursing college students and developing more specific programs on personality and self-control.