Purpose: The study was designed to identify influencing and mediating factors of health behaviors of stroke patients based on the hypothetical model constructed in this study. Methods: Non-experimental correlational research design was used. One hundred and five stroke patients were conveniently selected from one university hospital located in Incheon. Data were collected with survey and analyzed by path analysis to examine the significant influencing and mediating factors of health behaviors in stroke patients. Results: Age, diagnosis, disability in ADL, knowledge related to health behavior, and self-efficacy had significant direct causal influences on health behavior. And it was shown that knowledge and self-efficacy mediated influence of cohabitation status with family( whether or not living together with family) on health behavior. Self-efficacy also mediated influence of knowledge on health behavior. Conclusion: From the results, it was proposed that providing knowledge related to health behavior and enhancing self-efficacy by educating skill necessary for health behaviors and promoting health related beliefs might increase health behavior particularly for stroke patients living together with family.