Purpose: The purpose of this study was to identify the factors influencing depression of married immigrant women in Korea. Methods: Participants included 127 married immigrant women who met eligibility criteria and agreed to participate in the study. Participants were evaluated for subjective assessment of married immigrant-related constructs using a self-report questionnaire, for depression, acculturation stress, and social support. The analysis was done using SPSS for Windows, version 18.0, and included stepwise regression. Results: The major findings were as follows; 1) Depression significantly differed according to native country, length of residence in Korea, education, family monthly income, household and primary support. 2) There were significant relationships between marital life satisfaction (r=-.80, p<.001), acculturative stress (r=.78, p<.001), and social support (r=-.20, p=.025). 3) Marital life satisfaction, family monthly income, acculturative stress, primary support and social support were significant factors, which explained 84.6% of the variance in depression (F=138.04, p<.001). Multiple regression analysis revealed that a powerful predictor of depression for married immigrant women was marital life satisfaction. Conclusion: Based upon the findings, this study provides useful information that could assist in reducing depression among married immigrant women, and indicates that nursing interventions are needed.