Objective: The purpose of this study was to obtain the basic data for the establishment of the curriculum from the analysis of knowledge and attitudes about AIDS among dental hygiene students. Methods: Data was collected from the students of two colleges majoring in dental hygiene in Daegu, using questionnaire. They were the students of total 390. The analysis was made using t-test, (one-way ANOVA), and multiple linear regression analysis. These were conducted using SPSS 14.0 version. Results: The horizontal and vertical transmission in percent correct knowledge of HIV infection, most of the questions asked of respondents knew the correct answer, AIDS attitudes in the community education hours to receive AIDS education is important then the response was highest at 88.2 percent. AIDS knowledge is based on clinical practice, and AIDS attitudes in accordance with the educational experience of the average difference between groups investigated showed statistically significantly. HIV knowledge and attitudes, no oil, depending on the educational experience of the average difference between groups investigated showed statistically significantly. The grade, the higher knowledge of HIV was found to be lower in a statistically significant negative relationship showed (p<0.001), clinical experience, the more experience, knowledge of HIV was higher statistically significant positive showed a relationship (p<0.001), a higher attitude about HIV AIDS knowledge was higher showed a statistically significant positive relationship (p<0.001). Conclusion: Dental hygiene to prevent infection associated with AIDS in the curriculum and hands-on curriculum to enhance patient care through the AIDS patients in clinical management after graduating as a dental hygienist at the ethical responsibility is considered to be very strong.