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Prognostic Significance of Interactions Between ER Alpha and ER Beta and Lymph Node Status in Breast Cancer Cases
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  • Prognostic Significance of Interactions Between ER Alpha and ER Beta and Lymph Node Status in Breast Cancer Cases
  • Prognostic Significance of Interactions Between ER Alpha and ER Beta and Lymph Node Status in Breast Cancer Cases
저자명
Han. Shu-Jing,Guo. Qing-Qing,Wang. Ting,Wang. You-Xin,Zhang. Yu-Xiang,Liu. Fen,Luo. Yan-Xia,Zhang. Jie,Wang. You-Li,Yan. Yu-Xian
간행물명
Asian Pacific journal of cancer prevention : APJCP
권/호정보
2013년|14권 10호|pp.6081-6084 (4 pages)
발행정보
아시아태평양암예방학회
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정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

Objective: Both estrogen receptors, ER alpha ($ER{alpha}$) and ER beta ($ER{eta}$), are expressed in 50-70% of breast cancer cases. The role of $ER{alpha}$ as a prognostic marker in breast cancer has been well established as its expression is negative correlated with tumor size and lymph node metastasis. $ER{eta}$ is also a favorable prognostic predictor although this is less well documented than for $ER{alpha}$. Materials and Methods: To explore whether ERs independently or together might influence clinical outcome in breast cancer, the correlation between the ERs with the clinicopathological features was analyzed in 84 patients. Results: $ER{alpha}$ expression negatively correlated with tumor stage (r=-0.246, p=0.028) and tended to be negatively correlated with lymph node status (r=-0.156, p=0.168) and tumor size (r=-0.246, p=0.099). Also, $ER{eta}$ was negatively correlated with nodal status (r=-0.243, p=0.028), as was coexpression of $ER{alpha}$ and $ER{eta}$ (p=0.043, OR=0.194, 95% CI= 0.040-0.953). Conclusion: Coexpression of ERs might serve as an indicator of good prognosis in breast cancer patients.