Real time control (RTC) can be broadly defined as a system that dynamically adjusts the operation of facilities in response to online measurements in the field to maintain and meet the operational objectives, both during dry and wet weather conditions. RTC adds a dynamic component that is actively adjusted in real time based on system conditions. In terms of reducing or eliminating sewer flooding, CSOs and/or managing flows, implementation of RTC has various benefits to sewer system operation. It has been emerging as an attractive approach, but related elements (such as framework for the application, its components and equipments, aspects to be considered) towards its application on sewer systems have not been throughly introduced so far. The main goal of this study is to review several applications of RTC and firm guidelines published abroad, and finally to provide a framework for the proper application of RTC on sewer systems.